Lymphedema Research

The following information outlines recent and currently ongoing projects relevant to the treatment and management of lymphedema. The research is sub-categorized to assist the reader in finding research relevant to particular areas of interest.

 
CDT Combined Decongestive Therapy

 

A systematic review of the evidence for complete decongestive therapy in the treatment of lymphedema from 2004 to 2011.
Lasinski BB, McKillip Thrift K, Squire D, Austin MK, Smith KM, Wanchai A, Green JM, Stewart BR, Cormier JN, Armer JM.
Lymphedema Therapy and The Boris-Lasinski School, Woodbury, NY. August 4, 2012

Lymphedema: Current Issues in Research and Managment
Jeanne A. Petrerk, MD; Peter I. Pressman, MD; and Robert A. Smith, PhD
CA-A Cancer Journal For Clinicians Vol 50 NO.5 September/October 2000: 292-307 (2000)

Retrospective trial of complete decongestive physical therapy for lower extremity secondary lymphedema in melanoma patients
Eli Carmeli - Roberto Bartoletti
Tel Aviv University. Support Care Cancer 19: 141-147 (2011)

The treatment of lymphedema related to breast cancer: a systematic review and evidence summary
Lyn Kligman, Rebecca K.S Wong, Mary Johnston, Nancy S. Laetsch, Members of the Supportive Care Guidlines Group of Cancer Care Ontario's Program in Evidence-based Care
Support Care Cancer 12: 421-431 (2004)

Complex Physical Therapy of the Lymphodematous Leg
Judith R. Casley-Smith, Ph.D., Michael R. Mason, M.C.S.P., M.A.P.A., R. Gwyn Morgan, M.B., F.R.C.S, F.R.A.C.S., John R Casley-Smith, D.Sc. (Oxen & Adel), M.D., F.I.C.A
International Journal of Angiology 4: 134-142 (1995)

3.1. Therapy of lymphoedema, lipoedema

3.1.1. Badger CM, Peacock IL, Mortimer P. A randomised con- trolled parallel group clinical trial comparing multilayeer ban- daging followed by hosiery versus hosiery alone in the treat- ment of patients with lymphoedema of the limb. Cancer 2000; 88: 2832–37.

3.1.2. Johansson K, Albertsson M, Ingvar C, Ekdahl C. Effects of compression bandaging with or without manual lymph drainage treatment in patients with postoperative arm lym- phedema. Lymphology 1999 32: 103–10. Comment in: Lym- phology 2000; 33: 69–70.

3.1.3. Bertelli G, Venturini M, Forno G, Macchiavello F, Dini D. Conservative treatment of postmastectomy lymphedema: A controlled, randomized trial. Ann Oncology 1991; 2: 575–7.

3.1.4. Andersen L, Höjris I, Erlandsen M, Andersen J. Treatment of breast-cancer-related lymphedema with or without manual lymphatic drainage. A randomised study. Acta Oncologica 2000; 39: 399–405.

P. Hutzschenreuter, H. Brummer, K. Eberfeld:
Experimental and clinical studies of the mechanism of the effect of manual lymph drainage therapy. Z. Lymphol. 1989. 13: 62-64

M.L. McNeely et. al:
Conservative and Dietary Interventions for Cancer-Related Lymphedema. Cancer, 2010; 11.

Mayrovitz, HN, S Davey, E Shapiro:
Localized tissue water changes accompanying one manual lymphatic drainage (MLD) therapy session assessed by changes in tissue dielectric constant inpatients with lower extremity lymphdema. Lymphology 41 (2008), 87-92

Decongestive lymphatic therapy for patients with cancer-related or primary lymphedema.
Szuba A, Cooke JP, Yousuf S, Rockson SG.
Stanford Lymphedema Center, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA.
PubMed - National Library of Medicine

Complex decongestive physiotherapy for patients with chronic cancer-associated lymphedema.
Liao SF, Huang MS, Li SH, Chen IR, Wei TS, Kuo SJ, Chen ST, Hsu JC.
Department of Physical Medicine and Rehabilitation, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua 500, Taiwan.
PubMed - National Library of Medicine

The effect of complete decongestive therapy on the quality of life of patients with peripheral lymphedema.
Comment in: Lymphology. 2002 Jun;35(2):44-5. Weiss JM, Spray BJ.
Cox Regional Center for Sports Medicine and Rehabilitation, Springfield, Missouri 65807, USA.

Effects of compression bandaging with or without manual lymph drainage treatment in patients with postoperative arm lymphedema.
Johansson K, Albertsson M, Ingvar C, Ekdahl C.
Department of Physical Therapy, Lund University Hospital, Sweden. Comment in:

Clinical Trial Controlled Clinical Trial PMID: 10494522 [PubMed - indexed for MEDLINE]

Prospective trial of complete decongestive therapy for upper extremity lymphedema after breast cancer therapy.
Mondry TE, Riffenburgh RH, Johnstone PA.
Breast Health Center, Naval Medical Center, San Diego, California 92134-1005, USA.
Publication Types: Evaluation Studies PMID: 15000494 [PubMed - indexed for MEDLINE]

Efficacy of complete decongestive therapy and manual lymphatic drainage on treatment-related lymphedema in breast cancer.
Int J Radiat Oncol Biol Phys. 2007 Mar
Koul R, Dufan T, Russell C, Guenther W, Nugent Z, Sun X, Cooke AL. Department of Radiation Oncology, CancerCare Manitoba, Winnipeg, MB, Canada.

Long-term management of breast cancer-related lymphedema after intensive decongestive physiotherapy.
Breast Cancer Res Treat. 2007 Mar
Vignes S, Porcher R, Arrault M, Dupuy A. Department of Lymphology, Hôpital Cognacq-Jay, Site Broussais, 102 rue Didot, 75014, Paris, France.

Predictive factors of response to intensive decongestive physiotherapy in upper limb lymphedema after breast cancer treatment: a cohort study.
Breast Cancer Res Treat. 2006
Vignes S, Porcher R, Champagne A, Dupuy A. Department of Lymphology, Hôpital Cognacq-Jay, Université Paris, France.

Breast cancer-related lymphedema–what are the significant predictors and how they affect the severity of lymphedema?
Breast J. 2006 Nov-Dec
Soran A, D'Angelo G, Begovic M, Ardic F, Harlak A, Samuel Wieand H, Vogel VG, Johnson RR. Magee-Womens Hospital, Pittsburgh, Pennsylvania 15213, USA.

Complex decongestive physiotherapy for patients with chronic cancer-associated lymphedema.
J Formos Med Assoc. 2004 May
Liao SF, Huang MS, Li SH, Chen IR, Wei TS, Kuo SJ, Chen ST, Hsu JC. Department of Physical Medicine and Rehabilitation, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua 500, Taiwan.
PMID: 15216399 [PubMed - indexed for MEDLINE]

Effect of Complex Decongestive Therapy on edema and the quality of life in breast cancer patients with unilateral lymphedema
Lymphology, 2007, 40, pp 143 – 151. S.J. Kim et al
LLLT Combined With CDT in BRCA-related Lymphedema
Currently Ongoing
Sponsor: New York University School of Medicine
Principal Investigator: Theresa Denham, MD


Complete Decongestive Therapy (CDT) for Treatment of Head and Neck Lymphedema
Currently Ongoing
Sponsor: M.D. Anderson Cancer Center
Principal Investigator: Jan S. Lewin, PhD

 
 
Peripheral Lymphedema

C.C Campisi, M. Ryan, C.S. Campsi, P. Di Summa, F. Boccardo, C. Campisi.  Intermittent Negative Pressure Therapy In The Combined Treatment Of Peripheral Lymphedema. Lymphology 48 (2015) 197-204

Janice N. Cormier, MD, MPH, Loren Rourke, MD, Melissa Crosby, MD, David Chang, MD and Jane Armer, RN, PhD. The Surgical Treatment of Lymphedema: A Systematic Review of the Contemporary Literature (2004 - 2010) Ann Surg Oncol (2012). 19:642-651

Cormier JN, Rourke L, Crosby M, Chang D, Armer J. The Surgical Treatment of Lymphedema: A Systematic Review of the Contemporary Literature (2004-2010).  Ann Surg Oncol. Aug 24 2011.

Franks, PJ, CJ Moffatt, DC Doherty, et al:
Assessment of health-related quality of life in patients with lymphedema of the lower limb.
Wound Repair Regen. 14 (2006), 110-118

Piller, NB, L Clodius: The use of a tissue tonometer as a diagnostic aid in extremity lymphoedema: A determination of its conservative treatment with benzo-pyrones.
Lymphology 9 (1976), 127-132

Mayrovitz, HN: Assessing lymphedema by tissue indentation force and local tissue water.
Lymphology 42 (2009), 88-98.

Anand, S, H Lal, BK Dhaon: Lymphedema of the lower extremity as a complication of local burns.
Burns 24 (1998), 767-769.

Are Peripheral Edema Lymphatics damaged by high pressure manual massage? Lymphology, 1995, 28, pp 21 – 30, o. Elska, M. Eliskova

The Diagnosis and Treatment of Peripheral Lymphedema
Lymphology,1995; 28: 113 – 117, International Society of Lymphology
 
 

 

Cancer Related

A. Zimmerman, M. Wozniewski, A. Szklarska, A. Lipowicz, A. Szuba: Efficacy of Manual Lympathic Drainage in Preventing Secondary Lymphedema After Breast Cancer Surgery. Lymphology 45 (2012) 103 - 112

Nicole L. Stout, Lucinda A. Pfalzer, Barbara Springer, Ellen Levy, Charles L. McGarvey, Jerome V. Danoff, Lynn H. Gerber, Peter W. Soballe: Breast Cancer-Related Lymphedema: Comparing Direct Costs of a Prospective Surveillance Model and a Traditional Model of Care. Phys. Ther. 2012 January; 92(1): 152-163.

Mei R. Fu, PhD, RN, ACNS-BC, FAAN: Seroma: A Preditor for Breast Cancer-Related Lymphedema. National Lymphedema Network October / December 2012.

Lyn Lingman, Rebeeca K.S. Wong, Mary Johnston, Nancy S. Laetsch: The Treatment of lymphedema related to breast cancer: a systematic review and evidence summary. Support Care Cancer (2004)

Current Options for prophylactic treatment of hereditary angioedema in the United States: patient-based considerations. Gower RG, Lumry WR, Davis-Lorton MA, Johnston DT, Busse PJ. University of Washington, Marycliff Allergy Specialists, Spokane, Washington, USA. Allergy Asthma Proc. 2012 May;33(3): 235-40.

Hamner, JB, MD Fleming: Lymphedema therapy reduces the volume of edema and pain in patients with breast cancer. Ann. Surg. Oncol. 14 (2007), 1904-1908.

Armer, JM: The problem of post-breast cancer lymphedema: Impact and measurement issues. Cancer Invest. 23 (2005), 76-83.

Szuba, A, JP Cooke, S Yousufm et al: Decongestive lymphatic therapy for patients with cancer-related or primary lymphedema. Am. J. Med. 109 (2000), 296-300

Casseroller, RG: The Vodder School:The Vodder method.  Cancer 83(12 Suppl American) (1998), 2840-2842

Dawes, DJ, S Meterissian, M Goldberg, et al:Impact of lymphodema of arm function and health-related quality of life in women following breast cancer surgery. J. Rehabil. Med. 40 (2008), 651-658

Trial of Decongestive Lymphatic Therapy for Lymphedema in Women With Breast Cancer "DELTA STUDY"
Currently Ongoing
Sponsor: Ontario Clinical Oncology Group (OCOG)
Study Director: Ian Dayes, MD, et al

Does Scar Massage Improve Postoperative Pain and Function in Women With Breast Cancer?
Currently Ongoing
Sponsor: University of British Columbia
Principal Investigator: Pauline Truong, MD

Outcomes After Perforator Flap Reconstruction for Breast Reconstruction and/or Lymphedema Treatment
Currently Ongoing
Sponsor: The National Institute of Lymphology
Principal Investigator: Marga F. Massey, MD

A Clinical Trial About the Contribution of Manual Lymph Drainage in Complex Physical Therapy for Patients With Lymphoedema Secondary to Mastectomy
Currently Ongoing
Sponsor: Hospital Universitario de la Princesa

Massage Therapy for Breast Cancer Treatment-Related Swelling of the Arms
Currently Ongoing
Sponsor: National Center for Complementary and Alternative Medicine
Principal Investigator: Michael J. Bernas, MS

Lymph taping and seroma formation post breast cancer
Journal of Lymphedema, 2010, Vol. 5, No. 2, J. Borman, N. Pillar

Post mastectomy Arm Lymphedema: Treated by Manual Lymph Drainage and Compression Bandage Therapy
European Journal of Physical Medicine and Rehabilitation, 1991; 1, 6. P. Hutzschenreuter

A randomized crossover study to compare the effects of manual lymph drainage (MLD) and self administered massage (SAM) in women with breast cancer-related lymphedema
The Journal of MLD UK. Vol 6, Issue 2, 2000. A.F. Williams et al

A randomized controlled crossover study of manual lymph drainage in women with breast cancer-related lymphedema
European Journal of Cancer Care. 2002 11 ($) pp 254 – 261. A.F. Williams

Can Manual Treatment of Lymphedema promote Metastasis?
Journal Soc. Integ. Oncol. 2006; 4, 1. K. Godette et al

Objective measurement of the effectiveness of a single session of Manual Lymphatic Drainage of primary and secondary lympoedema of the leg
Lymphology, 2002, 35 (suppl) pp 289 – 292. N.B. Pillar, R. Harris

PT Patients respond to Massage Technique (MLD)
Advance for Physical Therapists, 1990. M.P. Pronsati

 

Compression Garments

McNeely ML, Magee DJ, Lees AW, Bagnall KM, Haykowsky M, Hanson J: The addition of manual lymph drainage to compression therapy for breast cancer related lymphedema: a randomized controlled trial. Breast Cancer Res Treat. 2004 Jul;86(2):95-106.

Assessment of 3M Oedema Reduction System in the Treatment of Lymphoedema Compared to Commercial Short-stretch Bandage
Currently Ongoing
Sponsor: 3M
Principal Investigator: Christine Moffatt, Prof.

Lymph Taping

Retrospective Study on Manual Lymph Drainage with or without combined use of Elastic Sleeve
In Progress in Lymphology XIII, Elsevier Science Publishers B.V. 1991, pp 561 – 562. F. Ferla et al

Could Kinesio tape replace the bandage in decongestive lymphatic therapy for breast-cancer-related lymphedema? A pilot study.
Han-Ju Tsai, Hsiu-Chuan Hung, Jing-Lan Yang, Chiun-Sheng Huang, Jau-Yih Tsauo:
Support Care Cancer (2009)

What is the effectiveness of elastic taping for lymphedema reduction of individuals with lymphedema secondary to breast cancer?
Carrie Bonsutto. Department of Occupational Therapy School of Pharmacy and Health Professions. Creighton University. November 15, 2012.